Global warming in present days is a serious issue. The consequences of global warming and issues related to it are increasing in intensity and frequency. Exposures to hot weathers can lead to heat-related diseases like heat exhaustion, heat cramps, and heat stroke. 

Heme oxygenase-1 is also referred as heat shock protein 32. This important enzyme degrades heme, which is a pro-oxidant which forms antioxidant molecules. The reaction leads to biliverdin generation, divalent iron products, and carbon monoxide. Earlier studies have shown that heme oxygenase pre-treatment or gene infection can result in protection of tissues and cells against the oxidative damages. These benefits have been studied by both in vitro and in vivo methods.

The present study involves the study of role of heme oxygenase in heat-induced brain damage in rats. The multidisciplinary team of researchers from Taipei, Taiwan checked the RT-PCR (Reverse Transcriptase- Polymerase Chain Reaction) results which showed that heme oxygenase concentrations were maximum immediately after the heat exposure. While the immunoblot analysis showed a delay of one hour for reaching the maximum levels of heme oxygenase in rats after heat exposure. 

The study shows that Heme oxygenase is a potent protective molecule, which combats the cellular damage due to heat. Manipulating this molecule and its application can be used as a therapeutic approach towards heat-related damage.