As a recently discovered hepatoadipokine, chemerin is used for regulating adipocyte differentiation, activation of dendritic cells and macrophages and chemotaxis.  It can be said to be a protein involved with fat cell development and immunity, as well as regulation of sugar levels in muscles and liver. It has a connection with inflammation and obesity and has connection with development of type 2 diabetes. This also has an innate connection with diseases related to blood vessel and heart.

In case of performing any tests, the major samples from which the best can be determined are plasma, serum, cell culture supernates, cell lysates, tissue homogenates and a number of biological fluids.

Roles of chemerin:

This adipokine has a certain functions as autocrine / paracrine signaling for adipocyte differentiation and stimulates lipolysis. However, secretion content changes in the pre and post in vitro sessions. This also plays a role in metabolic function of mature adipocytes. Both studies associated with humans and mice have shown, such mediation of chemerin in lipolysis procedure.

As a natural chemoattractant, and as macrophages, have implicated in chronic inflammation of adipose tissue in obesity. So chemerin plays an important role in insulin resistance and pathogenesis of obesity. The levels are different in case of humans and mice.