With Sterol regulatory element-binding protein 1C (SREBP-1C), are transcription factors, that are used for determining adipogenesis and regulate the expression of genes controlling cholesterol and fatty acid biosynthesis. However, this being one of the most recently developed molecules, not much information can be said to be found in relation with humans.

They are indirectly required for fatty acid biosynthesis and cholesterol biosynthesis. There is a tyrosine residue that is left post any type of experiment that has been performed.

Where does the importance of Sterol regulatory element-binding protein 1C (SREBP-1C) rest?

Since, this is specifically associated with cholesterol biosynthesis, so one needs to check out how cholesterol is required in the human body. Cholesterol in general is required for building and maintenance of membranes and modulation of fluidity of membrane over a range of physiological temperature conditions. Since rate of production depends on cell type and organ, hence, cholesterol synthesis within the body starts off with one molecule of acetyl- CoA and one molecule of acetoacetyl-CoA that are hydrated to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA).

With high intake of cholesterol, the major function starts such as sensing of intracellular cholesterol by the protein SREBP (sterol regulatory element-binding protein 1 and 2) that is there on endoplasmic reticulum.  With cholesterol presence, this protein binds other proteins namely, SCAP (SREBP-cleavage-activating protein) and Insig 1 resulting in biosynthesis procedure.