Keratinocyte is a prominent epidermal cell whose primary function happens to be formation of an internal barrier, against various pathological bacteria, parasites, viruses, fungi, UV radiation, and water loss. There are a number of structural proteins associated with this keratinocyte such as lipids, enzymes, antimicrobial peptides, keratin and filaggrin.

At each stage, this cell is part of mitosis, and divides in itself within a specified time period. This has a very important role in healing of wounds. In this regard, autocrine is a substance that is produced by a cell, and shows its effects on the cell itself.

How is autocrine related to keratinocyte cells?

This protein, keratinocyte, is specifically part of the epidermis growth family. This is both an autocrine growth helping factor and acts as mitogen in case of astrocytes. Further research associated with this dual function is being undertaken with help of Mouse keratinocyte autocrine factor Elisa Kit. This is related to both epidermis growth factor (EGF) as well as growth factor alpha. While interacting with TGF/EGF-alpha receptor, it helps in promotion of growth of general epithelial cells, and stops growth of aggressive carcinoma cells in linear pattern. This is also associated with psoriasis-like skin phenotype.

As per recent study, this autocrine signalling network is said to be activated during in vitro cultivation and tissue repair.