Cell fragmentation and its final death is an important issue of the human production system. In this case, Apoptosis inducing factor is a flavoprotein that helps in triggering of DNA fragmentation of a cell, as well as chromatin condensation. This is done to induce specifically programmed death of cells. In this case, independent nuclei undergo apoptotic changes. The whole process kicks off with release of Apoptosis inducing factor by mitochondria that further enters cytosol to cell nucleus from where cells condense its chromosomes and fragment DNA molecules to finalise cell death. These have the unique capacity to start off condensation of peripheral chromatin that is independent of caspase.

What is its role in mitochondrial activity?

Since mitochondria are known as powerhouse of the cell, hence cell death is also a very important part of the whole system. With Mouse Apoptosis inducing factor Elisa Kit further research is being carried on in this regard. In that regard, soluble form of Apoptosis inducing factor is used for inducing ‘parthanatos’, which happens to be the fragmentation of chromosomal DNA that is independent of caspase. Since it lacked in the first N terminal amino acids of 120 protein type. In this case, Apoptosis inducing factor should also function as NADPH and NADH oxidase.

When alterations are done such as mutations that have happened due to deleting that further results in creation of mouse model having deficiency of complex 1. This deficiency mostly attacks children and adults and hence mouse models are used for fixing the problems associated with this deficiency.