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Chemokines are specifically proteins that are found in human body, and has a number of functions associated with it. Macrophages, that are have an important role in producing CCL3 and CCL4 proteins, help in stimulating endotoxins that are specifically bacterial in nature. For any infection, there are certain responses provided by immune system of humans, and this has an important role in modulating those immune reactions. The Human Macrophage Inflammatory Protein-3β is similarly, a protein that helps in activation of human granulocytes that can further lead to inflammation of neutrophilic aspects of human body. This also helps in synthesizing and releasing of cytokines that are pro-inflammatory in nature.
Important features of Human Macrophage Inflammatory Protein-3β:
This macrophage has a strong chemotactic base that is used to a great extent for attracting neutrophils. This has an important function in lymphoid tissues that are mucosal in nature, and has attraction towards epithelial cells by usage of dendritic cells. This protein has an attraction towards cord blood cells and bone marrow. Another very important aspect to note is that this macrophage inflammatory protein is found to be expressed in peripheries of blood B cells.
The Human Macrophage Inflammatory Protein-3β,MIP-3βELISA Kit has a very important role in immunological as well as inflammatory responses in human body. In case of normal lymphocyte homing, and recirculation, it role plays in trafficking of thymus T cells, and migration of B cells in lymphoid organs that are of secondary nature. This tissue is specifically expressed at high levels at lymph nodes, appendix and thymus.