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There are a number of cytokines that get inflammatory in nature. Encoded within CXCL12 gene, this Human Stromal Cell Derived Factor 1β is a chemokine protein specifically found in human bodies. As part of leukocyte family, this chemokine is induced within human body by means of stimuli that is pro inflammatory in nature such as lipopolysaccharide. It is specifically produced in two primary formats by cysteines and multiple disulphide bonds are formed. The most important role in this system happens to be inhibiting certain infections, and playing a protective role post myocardial infection. Acting as a positive regulator in terms of migration of monocytes, this acts in a negative manner in case of adhesion of monocyte.
This Human Stromal Cell Derived Factor 1β has a very important role in case of embryogenesis, and is chemotactic for lymphocytes. During this period, its primary function is to direct this migration of blood cells to that of liver of foetus and bone marrow that on the whole results in formation of large blood vessels. This role is specifically for babies that are about to be born, however, this cell has an important role to play in case of adults. In adults, it has a role in angiogenesis, which is done by recruiting of progenitor cells, that is specifically done by bone marrow. It also has an important role in carcinogenesis, and neovascularisation that is directly linked to progression of tumor.
A complete and detailed analysis of this can be found with help from Human Stromal Cell Derived Factor 1β (SDF-1β) ELISA Kit that shows important experiments that are being made in this domain.