There are certain specific proteins in human body that help in building immune system, and Human Calprotectin is definitely one of the most important protein that help in ensuring how immune system of human body functions. This antimicrobial type of protein is known for its metal-chelating quality and has a role in iron homeostasis in mammals especially. At times, in human body, there arises lack of calcium content. In such cases, this Human Calprotectin acts in a specific manner to sequester metals that are present in human body as zinc and manganese and ensure that they are used for benefit of the body.

By virtue of this metal sequestration, certain complicated microbial properties are generated and this has a direct contact with human body. This protein is soluble in water and has specific affinity towards metals as calcium, manganese and zinc. Rather, it reacts to a great extent with theses metals for benefit of the body. Also, most of ions in these metals can be bound due to presence of associated metals as well. There are certain individual monomers that are present within human body and this improves binding capacity of metals with this Human Calprotectin.

As part of cytosol content in granulocytes, this Human Calprotectin can be found in macrophages, monocytes, and a number of epithelial cells of squamous type. This is also present in lumen of intestines and plays a role in shedding of cells, secretion, death of cells, and finally cell disturbance on a greater note. Further research in humans is being carried out by means of Human Calprotectin (CALP) ELISA Kit.