In present times, in a set of experiments that are mostly used for testing quality of a particular drug, rats are used as modes of experiment. Since, there are a number of enzymes that are specific to rats, it is important that they are used in major tests and also there are certain enzymes that are specifically found in them and are to be used on a long term basis. The Rat heme oxygenase-1 is a specific protein coded gene that has usage in catalysing the oxidative cleavage of heme to that of biliverdin. Its basic lineage can be found in eukaryote, craniata, chordate, vertebrata and many others. There is an induction of this element within a rat body that shows its occurrence primarily in the endothelial cells, through means of ipsilateral context. This Rat heme oxygenase-1 is also found in pathogenesis of a number of renal diseases. This is useful in noting of messengial cells that acts as transactivator in regards to promotion of proximal issues. Having a role in promotional activities of base level, there are chances of singular or combined mutation sites in regards to this.

There are strong evidences that support activities of anti-oxidant proteins and resultant increase in oxidative stress which is fundamental causes in neurogenerative problems and regular ageing processes. As per latest tests that have been conducted with help of Rat heme oxygenase-1 (HO-1) ELISA Kit it is found that excessive accumulation of levels of bilirubin, results in presence of hyperbilirubinemia in rats. In this heme oxygenase-1 is a limiting factor in this regard.