The enzymes that are mostly present in human body are bound within a membrane and thus, result in formation of isoforms within that fixed place. The Human Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 is a specific type of extracellular yet membrane bound enzyme, that is found within the plasma membrane, and thus while taking care of tests that are associated with this, it is important that samples be taken specifically from homogenate of tissues, plasma, and serum. This enzyme is found in membranes that are associated with phagosomes as well as white blood cells that are neutrophil in nature, and has the function of engulfing microorganisms with regards to itself.

Clinical functions associated with Human Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4:

Since, this is an enzyme that is associated with extracellular space, it is activated within membranes that are associated with respiratory burst. Within the body, this generates superoxide, by transferring electrons that are placed within the cell, across the membrane, and couple it up with molecular oxygen that is associated with ingested bacteria and fungi. There are a number of processes that are associated with this reactive oxygen species, that can form the required hydrogen peroxide for the purpose. It is important to note that as per tests conducted with help of Human Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Elisa Kit, it has a major role to play in regards to atherosclerosis. Certain oxidase inhibitors associated with these results in creation of such reverse schemes in atherosclerosis. Also, in case of clinical benefits it acts in a great manner against influenza.