There are more and more patients with hypercholesterolemia under the condition of well-off life, and the age of patients also tends to be younger. Subtilisin, a protease, was first obtained from B. subtilis. Belonging to the subtilase class.

On the one hand, hypercholesterolemia is very effective. Subtilisin through the active site of serine residues on the peptide bond nucleophilic attack caused by protein hydrolysis, thus affecting the degradation of low-density lipoprotein receptor in familial hypercholesterolemia and other lipid-lowering treatment,play an important lipid-lowering effect. Subtilisin typically has a molecular weight of 20,000 to 45,000 daltons and is obtained from Bacillus amyloliquefaciens and other soil bacteria, in addition to being obtained from Bacillus subtilis. Many Bacillus bacteria can be a large number of secreted subtilisin protease. On the other hand, Subtilisin is also widely used in agriculture. The enzymatic modification of soy protein isolate by subtilisin was carried out, and the functional properties of the modified soy protein isolate were greatly improved.

In short, the rational use of Subtilisin can improve the quality of life of people and the socio-economic level.