Definition

Ciprofloxacin for the synthesis of third-generation quinolone antibacterial drugs, broad-spectrum antibacterial activity, good bactericidal effect, almost all of the antibacterial activity of bacteria than norfloxacin and enoxacin 2 to 4 times stronger, Enterobacter, Pseudomonas aeruginosa, Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus, Legionella, Staphylococcus aureus with antibacterial activity.

Purposes

The goods are highly efficient broad-spectrum antimicrobial agents. Pharmacological effects of fluoroquinolones, antibacterial spectrum with norfloxacin, the antibacterial activity is widely used in the most fluoroquinolones. In addition to Gram-negative bacilli have a high degree of antibacterial activity, still on Staphylococcus a good antibacterial effect on pneumococcus, Streptococcus is slightly worse than the role of Staphylococcus. The goods on the part of Mycobacterium, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, etc. also have an inhibitory effect. The drug's mechanism of action and bacterial resistance see norfloxacin. As fungicides, is generally believed that quinolones acting on the bacterial cell DNA helicase A subunit, inhibit DNA synthesis and replication and lead to bacterial death.

The clinical use of ciprofloxacin than norfloxacin for the wide, in addition to urinary tract infections, intestinal infections, gonorrhea, etc., can still be used to treat influenza by bacteria, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, (Including methicillin-resistant strains) and other bone and joint infections, skin and soft tissue infections and pneumonia, sepsis and so on, and so on, and so on, such as bacteria, Pseudomonas aeruginosa, Enterobacter cloacae, Frauenia bacilli, Staphylococcus. . Intravenous administration can be used for the treatment of heavier infections, such as Enterobacteriaceae bacterial sepsis, pulmonary infection, abdominal cavity, biliary tract infection and so on.

Adverse reactions

1、gastrointestinal reactions are more common, can be manifested as abdominal discomfort or pain, diarrhea, nausea or vomiting.

2、central nervous system reactions may have dizziness, headache, drowsiness or insomnia.

allergic reactions: rash, skin itching, even exudative erythema multiforme and angioneurotic edema. A small number of patients with photosensitive reaction.

4、can occur:

(1) seizures, mental disorders, irritability, confusion, hallucinations, tremors.

(2) hematuria, fever, rash and other manifestations of interstitial nephritis.

(3) crystalline urine, more common in high-dose applications.

(4) joint pain.

5、a small number of patients with serum aminotransferase can increase blood urea nitrogen and peripheral blood leukocyte decreased, mostly mild, and was transient.