Physical and chemical properties

Enrofloxacin, also known as enfluricarboxylic acid, belongs to fluoroquinolones of the chemical synthesis of antimicrobial agents, yellow or light yellow crystalline powder, bitter, insoluble in water, Soluble in sodium hydroxide solution, methanol and methyl cyanide and other organic solvents.

Pharmacokinetics

Enrofloxacin oral and intramuscular injection of the rapid absorption of more complete. 0.5 - 2 hours after taking the drug, reached the peak of the blood. In addition to the central nervous system, almost all of the tissue of the drug concentration is higher than plasma, which is conducive to systemic infection and deep tissue infection treatment. This product through the kidney and non-kidney way to eliminate, about 15% - 50% of the drug prototype through the urine excretion. Enrofloxacin metabolism in animals is mainly to get rid of ethyl and ciprofloxacin.

Pharmacological effects

Enrofloxacin for broad-spectrum bactericidal drugs, effects of mycoplasma. On E. coli, Klebsiella, Salmonella, Proteus, Pseudomonas aeruginosa, Haemophilus, Pasteurella multocida, Pasteurella hemolyticus, Staphylococcus aureus, Streptococcus, and so on, all have sterilization effect.

Enrofloxacin can be used as animal drugs. In animals, it has a long half-life and good tissue distribution, belonging to the broad-acting antibacterial agent. For Gram-positive bacteria, negative bacteria and fungi paste, Enrofloxacin has antibacterial effect. Enrofloxacin has been used in the breeding of fish Vibrio and Escherichia coli disease control.

Enrofloxacin for the synthesis of third-generation quinolone antibacterial drugs, also known as ethyl ciprofloxacin, October 4, 1996 approved by the FDA for livestock and aquatic products for quinolones antibiotics. With the bacterial DNA gyrase A subunit A binding, thereby inhibiting the enzyme cutting and ligation function, to prevent the bacterial DNA replication, and showed antibacterial effect. Has broad-spectrum antimicrobial activity, has a strong permeability, the goods on the Gram-negative bacteria have a strong role in the killing of Gram-positive bacteria, also have a good antibacterial effect, oral absorption is good, high and stable blood concentration, can be widely distributed in the organization, the metabolite of ciprofloxacin, there is still a strong antibacterial effect. Almost all of the pathogenic bacteria of aquatic animals are strong antibacterial activity. It is effective for severe infections caused by drug-resistant pathogens and has no cross-resistance with other antibiotics.