Basic concept of fibrinogen

Fibrinogen is a protein with the function of coagulation synthesized by the liver. Fibrinogen is the process of coagulation, thrombin excretion of fibrinogen A and B and the formation of monomeric proteins.In brief, It is a coagulation-related proteins, namely, coagulation factor!

Key Features

1. Fibrinogen and liver disease fibrinogen synthesis of the liver, mainly in plasma, also in platelets and megakaryocytes. Normal plasma concentration of 1.5 ~ 3.5g / L, so when the liver is severely damaged, the liver synthesis of fibrinogen function disorders, the plasma fibrinogen concentration decreased. Fibrinogen is a kind of plasma glycoprotein synthesized in the liver, which can be involved in the formation and development of thrombosis and coronary artery, it is an index of thrombosis status and one of the independent predictors of acute coronary events. Fibrinogen increased fibrinolytic activity prompted the body to reduce thrombosis.

2. Fibrinogen and nephrotic syndrome NS patients with changes in coagulation factors to fibrinogen levels increased the most obvious. Fibrinogen levels increased up to 10 g / L, which is due to increased synthesis of the results, which increased its loss from the urine in proportion to the amount, but the catabolic catabolic rate of fibrinogen is normal. There was a significant correlation between fibrinogen and cholesterol levels in patients with NS and a negative correlation between serum fibrinogen and serum albumin

3. Fibrinogen and atherosclerosis fibrinogen and cellulose and atherosclerotic plaque formation of the relationship is extremely close. It is known that fibrinolytic mechanisms are affected by a variety of factors, such as smoking, diabetes, especially high serum triglycerides, which can lead to increased plasminogen activator inhibitor, thereby reducing plasminogen synthesis. Blood viscosity is relatively high, which are conducive to the formation of cellulose. Fibrinogen is an acute phase protein, as the coagulation factor I from the blood into the arterial wall, in the role of thrombin into fibrin monomer secondary crosslinking to fibrin, can directly damage the endothelial cells adsorbed on the surface of red blood cells , So that increased incidence of arterial thrombosis, and promote rapid development of atherosclerotic plaques. In addition, plasma fibrinogen can be deposited in the vessel wall, accelerated atherosclerosis, it has been found in atherosclerotic plaques fibrin aggregates in the amount of group disease fibrinogen levels are increased, and have increased blood viscosity. Atherosclerosis is very characteristic of obstruction.

4. Fibrinogen and cardiovascular and cerebrovascular diseases in acute ischemic syndrome thrombosis studies have shown that plasma fibrinogen levels are independent risk factors, patients with coronary artery disease in patients with high levels of plasma fibrinogen, myocardial infarction The extent of fibrinogen is also closely related to the degree of increase. Patients with unstable angina, in its occurrence before myocardial infarction, often elevated plasma fibrinogen levels. In the course of myocardial infarction, reinfarction occurred in more than 7g / L in patients with fibrinogen levels.

5. Fibrinogen and hemorheology found fibrinogen and whole blood viscosity, plasma viscosity, erythrocyte sedimentation rate and platelet aggregation was significantly positively correlated, suggesting that plasma fibrinogen levels increased, can increase blood viscosity. Red roar aggregation increased, increased platelet aggregation, so that the blood in the hypercoagulable state to promote thrombosis. Plasma fibrinogen content increased because of its large molecular weight. High concentration, but also has the role of polymerization, in addition to red blood cells outside the increase in blood viscosity is an important factor; Plasma fibrinogen content in the occurrence of the disease to determine the development of great significance. In this case,

6. Fibrinogen and other factors affect fibrinogen levels of other factors, such as genetic predisposition, age, hyperlipidemia, smoking, primary hypertension, obesity, oral contraceptives and pregnancy, etc., are Is a risk factor for elevated plasma fibrinogen.

Drug use instructions

For congenital hypofibrinogenemia, primary and secondary fibrinolysis caused by low fibrinogen hyperlipidemia.

Intravenous infusion, 60 drops / min, depending on the condition may be.

Precautions

Occasionally allergic reactions. Only for intravenous infusion, the speed should be slow, rapid overdose can occur intravascular coagulation. Repeated infusion can produce anti-fibrinogen antibody, a few people can form thrombosis. Can become a vector of transmission of infectious hepatitis. Once the product is dissolved, should be used immediately. After dissolution should be clear and slightly opalescent solution, allowing a small amount of protein particles exist, infusion should be used with a blood transfusion filter. Thrombophlebitis, arterial thrombosis, myocardial infarction, heart failure were hanged.