The scientific definition of estradiol

Estradiol is a skin-absorbed estrogen therapeutic. 17-β estradiol secretion of female ovarian secretion, while avoiding the side effects caused by oral (breast pain, weight gain, high blood pressure, gallstones and liver dysfunction, etc.). Estrogen can induce cells to synthesize DNA, RNA and various proteins within the corresponding tissues.

Adaptation of estradiol

1. Supplemental estrogen deficiency. Commonly used in the treatment of female gonadal dysfunction, bilateral ovariectomy, atrophic vaginitis, genital dryness, menopausal syndrome such as hot flashes, sweating and mental, neurological symptoms.

2. The use of estrogen treatment of metastatic breast cancer, 40% can be achieved.

3. For the treatment of advanced prostate cancer, symptoms improved significantly, reduce pain, testicular removal after the addition of estrogen therapy.

4 to prevent osteoporosis, for the early prevention of menopause due to lack of estrogen caused by rapid loss of bone.

5. The treatment of acne (acne), in men can be used for heavier cases, in women can use estrogen and progesterone compound preparation.

6. Leukopenia, for malignant tumors caused by chemotherapy or radiotherapy of leukopenia, a significant increase in the effect of white blood cells.

Use as a postnatal contraceptive.

8. Refund the milk.

[Endocrine system drugs] estrogen, progesterone and related drugs

Estradiol is a key natural estrogen secreted by ovarian mature follicles, which can promote and regulate the normal development of female organs and secondary sexual characteristics.

Estradiol (o) estradiol C18H24O2 is a steroidal estrogen. There are two types of α, β, α-type physiological effects. Wintersteiner et al. (1935) have been extracted from pregnant horses, and can also be obtained from pregnant women urine, human placenta, pig ovary. A testis or urine also exists. Because it has a strong role in sex hormones, so that it or its ester is actually the most important ovarian secretion of sex hormones. The benzoate ester of estradiol is used as one of the reference materials for determining the international unit of sex hormone titer.

Clinical significance of estradiol

1. increased seen in female precocious puberty, male breast development, pregnancy (especially twins or multiple births), estrogen secretion tumor, ovulation drugs (such as chlorofen), male feminization, ovarian cancer, anovulatory dysfunctional uterine bleeding Cirrhosis and so on.

2. To reduce the occurrence of ovarian cancer, hydatidiform mole, intrauterine stillbirth, pregnancy-induced hypertension syndrome, hypothalamic tumor, hypopituitarism, ovarian dysfunction, ovariectomy, pubertal delay, primary and secondary amenorrhea, Oral contraceptives.

3, increased the value of estradiol pathology 1) ovarian disease: ovarian granulosa cell tumor, ovarian tumor, ovarian fat cell tumor, sex hormone tumor, etc., both the performance of ovarian hyperthyroidism, estradiol secretion increased. 2) heart disease: myocardial infarction, angina, coronary artery stenosis. 3) Other: systemic lupus erythematosus, cirrhosis, male obesity.

4, estrogen reduce the pathological causes of 1) ovarian disease: lack of ovarian or low development, primary ovarian failure, ovarian cysts. 2) pituitary amenorrhea or infertility. 3) other: hypothyroidism or hyperthyroidism, Cushing's syndrome, Addison's disease, malignancies, a wide range of infection, renal insufficiency, brain and pituitary focal lesions, can make plasma estrogen alcohol.

Adverse reactions

1, not common or rare but should pay attention to adverse reactions: 1).irregular vaginal bleeding, drip, breakthrough bleeding, long-term bleeding or amenorrhea; 2).drowsiness; 3).frequent urination or urination pain; 4).severe or sudden headache ; 5).sudden loss of co-ordination, involuntary emergency action (chorea); 6).chest, epigastric (stomach), groin or leg pain, especially the gastrocnemius muscle pain, arm or leg weakness or numbness; 7).shortness of breath, 8).a small tumor in the breast; 9).mental depression; 10).eye conjunctiva or skin yellow dye, pay attention to hepatitis or biliary obstruction (bleeding or blood clots); 11).blood pressure; 12).rash; 13).sticky white curd-like vaginal discharge (candidiasis).

Precautions

1. Do not smear or paste in the breast or vulva.

2. People with skin diseases and skin allergies should not be used.

3. Should pay attention to patch off. Should not be soaked in hot water bath time is too long, to avoid rubbing the skin patch parts directly, should be replaced after the new film off. Stick with the time and release film time, according to the original date for film.

4 liver, renal dysfunction were hanged.

5 bogey for the breast, vulva and vaginal mucosa.

6 [serum reference range] (unit: ng / L)

Male: <0.2

Women: follicular phase <0.3, luteal phase 1-16, gestation 2-243, menopause <0.2

Methods for examination of estradiol

Male and female estradiol abnormalities, then check, generally including blood specimen examination and urine specimen examination two kinds. Blood specimens, check the day before the late 8 o'clock, should begin fasting 12 hours, so as not to affect the test results. Urine specimens, check the need for normal diet, normal activities, do not deliberately drink too much water, neither can not move in bed and can not be too intense exercise. Other inspection precautions strictly according to hospital doctors can.