The main component of hyaluronic acid

Hyaluronic acid hyaluronic acid is an acidic mucopolysaccharide, 1934, Columbia University professor of ophthalmology Meyer first isolated from bovine vitreous body of the substance. Hyaluronic acid with its unique molecular structure and physical and chemical properties in the body shows a variety of important physiological functions, such as lubricating joints, regulating the permeability of the vascular wall, regulating protein, water and electrolyte diffusion and operation, and promote wound healing. Especially important is that hyaluronic acid has a special role in water retention, is found in the nature of the best moisturizing substances, known as the ideal natural moisturizing factor (Natural moisturizing factor, NMF, such as: 2% pure hyaline (Hyaluronic acid) HA is widely distributed in various parts of the human body, in which the skin also contains a lot of hyaluronic acid.Human skin maturation and aging process But also with the content of hyaluronic acid and metabolism and changes, it can improve skin nutrition and metabolism, so that the skin soft, smooth, wrinkle, increase flexibility, prevent aging, while moisturizing is a good transdermal absorption enhancer. Other nutrients with the use, can play a better role in promoting nutrient absorption.

The main use of hyaluronic acid

Hyaluronic acid liquid 1, for the high clinical value of biochemical drugs, widely used in various types of ophthalmic surgery, such as crystal implantation, corneal transplantation and anti-glaucoma surgery. It can also be used to treat arthritis and accelerate wound healing. Its use in cosmetics, can play a unique role in the protection of the skin can keep the skin moist and smooth, delicate and soft, elastic, wrinkle-free, anti-wrinkle, beauty care and restore the role of skin physiological function.

2, Uses It can be used in cosmetics cream, cream, honey, milk, mask, shampoo and other products to keep the skin and hair moisture, nourish the skin, hair, increase gloss and prevent chapped skin and wrinkles. Hyaluronic acid skin care cream reference formula and preparation process: take stearic acid 77g, liquid paraffin 10.5g, white vaseline 35g, glycerol monostearate 35g mixed, heated to 80℃, the other water 235 g, adding sodium dodecyl sulfate 0.7g and triethanolamine 2.45g, heated to 8 0℃, and then add 10% nipagin alcohol solution 3.5mL and glycerin 14g, the oil phase slowly into the water phase, edge down the same direction in the stirring, when the temperature dropped to about 70℃, 0. 5% hyaluronic acid solution 220mL into the liquid, and add a little fragrance, rapid mixing to semi-solid can be packaged.

3, treatment of arthritis and accelerate wound healing.

Side effects of hyaluronic acid

Occasionally urticaria, dermatitis pruritus, should be discontinued, appropriate treatment.

Sometimes pain, swelling, blocking water flow infiltration, and occasionally edema, redness, heat, local weight feeling.

It is well known that hyaluronic acid (hyaluronic acid) in a material over the skin of Shar Pei's skin, it will cause it to produce so many wrinkles. The excess of hyaluronic acid is likely due to the name "hyaluronic acid synthase 2" genes caused by over-activation.

When the synthesis of enzyme gene after activation, the human body will produce the appropriate enzyme to break down, destroy the excess part, play a certain "self-regulation" effect. Hyaluronidase can eliminate excess hyaluronic acid, thereby eliminating side effects.

Synthesis of hyaluronic acid

Hyaluronic acid production process and technology determines the quality of the pros and cons of the difference, so the use must be the source of the correct production of the product can have therapeutic effect. In general, there are three refining methods:

1, animal tissue: the main raw material is the comb and bovine vitreous body. The raw material is degreased with acetone or ethanol, dehydrated, soaked with distilled water, filtered, treated with sodium chloride and chloroform solution, then added with trypsin to obtain mixed solution, and finally treated with ion exchanger, and purified to obtain refined transparent Acid. This method is very low extraction rate, only about 1%, the separation process is complex, resulting in expensive hyaluronic acid, up to 5,000 US dollars / kg, limiting the amount of use in cosmetics.

2, microbial fermentation: glucose as a carbon source of fermentation broth. After fermenting for 48 hours at the end of the fermentation, the mycelia and impurities are removed by filtration and then subjected to a simple operation such as alcohol precipitation to obtain a highly pure product. Hyaluronic acid produced by fermentation, the advantage is based on commodity design to set the size of molecular weight. The key to the fermentation method is the choice of bacteria, multi-selection of Streptococcus, Lactococcus class.

3, chemical synthesis: the use of natural enzyme polymerization; first polysaccharide polymer synthesis, "hyaluronic acid oxazoline derivatives," and then add water-hydrolyzing enzymes, derivatives and enzymes to produce complex, and finally Hyaluronic acid was synthesized by removing the enzyme in the 90 ° C reaction solution. Synthetic method can greatly reduce the cost of manufacturing hyaluronic acid, but the structure is less pure.

Hyaluronic acid is also a product, because the source of raw materials and technology into the differences, the effect has a significant impact. Product concentration can not be used as a reference product selection, purity, molecular weight, 3D three-dimensional structure will directly affect the water absorption of hyaluronic acid effect. Usually the larger the molecular weight, the more complete the network structure, the best water absorption effect. Fang Jian care products, cosmetics popular, but many industry-made hyaluronic acid, cheap, but not necessarily effective. Even the introduction of oral hyaluronic acid, after gastrointestinal absorption will be broken down into carbohydrates and amino acids in the small unit molecules, or through the steps such as autologous synthesis can be generated in the skin, connective tissue, the effect must be discounted.