CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or
IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the
receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells
through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes),
peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker
for identifying memory and effector T cells. Studies have shown that CD127 expression is
down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and
conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature
and immature T cells as well as immature B cell proliferation and development.
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